Summary: Epilepsy is a circuit-level brain disorder characterized by hyperexcitatory seizures with unclear mechanisms.Here, we investigated the causal roles of calretinin (CR) neurons in the posterior intralaminar thalamic nucleus (PIL) in hippocampal seizures.Using read more c-fos mapping and calcium fiber photometry, we found that PIL CR neurons
New DArT markers for oat provide enhanced map coverage and global germplasm characterization
Abstract Background Genomic discovery in oat and its application to oat improvement have been hindered by a lack of genetic markers common to different genetic maps, and by the difficulty of conducting whole-genome analysis using high-throughput markers.This study was intended to develop, characterize, and apply a large set of oat genetic markers b
Susceptibility of Ph-positive all to TKI therapy associated with Bcr-Abl rearrangement patterns: a retrospective analysis.
BackgroundTyrosine kinase inhibitors (TKIs) have demonstrated success in the treatment of acute lymphoblastic leukemia (ALL) in patients that express BCR-ABL rearrangements (Philadelphia chromosome [Ph]).The current study aimed to assess the efficacy of TKIs and prognostic factors in the treatment of adults with Ph+-ALL.MethodsIn this multicenter r